Multiple Detector-Row CT in Gastric Cancer Staging: Prospective Study

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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52605#.VJy5NcCAM4

Author(s)

Lorenzo Bruno^1*, Lucia Barni¹, Gaia Masini¹, Sabrina Pacciani¹, Edvige Lucarelli², Antonella Masserelli², Daniela Tomcykova³, Filippo Melli¹, Luca Boni³, Giancarlo Freschi¹, Paolo Bechi¹

Affiliation(s)

¹Surgery and Translational Medicine, University of Florence, Florence, Italy.
²Diagnostic Imaging 4, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
³Clinical Trials Coordinating Center, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

ABSTRACT

The aim of this study was to evaluate the accuracy of multiple detector computed tomography (MDCT) in the preoperative staging of gastric cancer, prospectively comparing CT findings with pathological findings at surgery, in a single-center study. A total of 19 consecutive patients with primary cancer recruited between March and July 2014 were submitted to preoperative MDCT staging according to a standard protocol. All diagnostic procedures were performed by dedicated radiologists who were unaware of the final pathological results. Subsequently, 16 patients underwent surgical treatment and 15 were finally included in the study. The primary tumor was detected at CT in all 15 cases. CT results for T staging were in agreement with pathological findings in 12 of 15 cases, with overall accuracy of 80%. Stage-specific sensibility was high for advanced stages (sensibility for T1, T3, and T4 resulted 60%, 85.7%, and 100%, respectively), while earlier stages showed higher specificity (specificity for T1, T3, and T4 resulted 100%, 75%, and 91.7%, respectively). Overall N staging accuracy was 86.7%, with 13 of 15 patients correctly staged. Stage-specific sensibility was 75% for N0 and 100% for N3, while specificity was 100% for N0 and lower for advanced stages. Accuracy for peritoneal involvement was 100%. Our findings show a good performance of the diagnostic protocol performed with MDCT tested in this study.

KEYWORDS

Gastric Cancer, MDCT, Staging, Oncologic Imaging

Cite this paper

Bruno, L. , Barni, L. , Masini, G. , Pacciani, S. , Lucarelli, E. , Masserelli, A. , Tomcykova, D. , Melli, F. , Boni, L. , Freschi, G. and Bechi, P. (2014) Multiple Detector-Row CT in Gastric Cancer Staging: Prospective Study. Journal of Cancer Therapy, 5, 1438-1449. doi: 10.4236/jct.2014.514145.

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