Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan

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ABSTRACT

Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients’ files with systemic lupus erythematosus aged 12 to 73 years old, who fulfilled the American College of Rheumatology (ACR)’s criteria. Antinuclear autoantibodies (ANA) were searched by indirect immunofluorescence. Anti-DNA native autoantibodies, extractable nuclear anti-antigens autoantibodies (anti-Sm, anti-SSA, anti-SSB and anti-RNP) and anti-phospholipids autoantibodies have been searched by ELISA technic. Results: The most frequent clinical manifestations were: articular damages (86.32%), cutaneous and mucosal lesions (71.79%) and fever (76.67%). Kidney damages have been noticed in 40.17%. Neurologic manifestations have been observed in 36.75%. Pericarditis and pleurisies have been noticed in 22.22% and 11.97% of cases, and anaemia in 86.32% of cases. ANA have been detected in 94.12% of cases, anti-DNA native’s autoantibodies in 73.53% and anti-Sm autoantibodies in 75% of cases. Anti-SSA and anti-SSB autoantibodies were respectively in 75% and 56.25% of cases. Anti-RNP autoantibodies were in all the patients, and anti-phospholipids autoantibodies were in 37.50% of cases. Conclusion: Systemic lupus erythematosus of Ivorian black subject is characterised by high prevalence of autoantibodies, mostly Anti-RNP.

Cite this paper

Gbané-Koné, M. , Ouattara, B. , Djaha, K. , Megne, E. , Ngandeu, A. , Coulibaly, A. , Eti, E. and Kouakou, M. (2015) Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan. Open Journal of Rheumatology and Autoimmune Diseases, 5, 28-35. doi: 10.4236/ojra.2015.52006.

References

[1] Haddouk, S., Ben Ayed, M., Baklouti, S., Hachicha, J., Bahloul, Z. and Masmoudi, H. (2005) Autoanticorps dans le lupus érythémateux systémique : Profil et corrélations cliniques . Pathologie Biologie, 53, 311-317.
http://dx.doi.org/10.1016/j.patbio.2004.10.004
[2] Ghedira, I., Sakly, W. and Jeddi, M. (2002) Caractéristiques cliniques et sérologiques du lupus érythémateux systémique: A propos de 128 cas. Pathologie Biologie, 50, 18-24.
http://dx.doi.org/10.1016/S0369-8114(01)00262-0
[3] Meyer, O. (2002) Lupus systémique chez les non-Caucasiens. Revue du Rhumatisme, 69, 801-808.
http://dx.doi.org/10.1016/S1169-8330(02)00385-X
[4] Daboiko, J.C., Gueret, M., Eti, E., Ouali, B., Ouattara, B., Gbané, M. and Kouakou, N.M. (2004) Profil clinique et évolutif du lupus érythémateux systémique: A propos de 49 cas colligés au CHU de Cocody. Médecine d’Afrique noire, 51, 143-146.
[5] Iba Ba, J., Nzenze, J.R., Biteghe, B., Missounga, L., Bignoumba Ibouili, R., Moussavou Kombila, J.B. and Boguikouma, J.B. (2011) Profil clinique, biologique et évolutif du lupus systémique en milieu hospitalier à Libreville. Médecine d’Afrique noire, 58, 551-559.
[6] Fall, S., Pouye, A., Ndiaye, F.S., Ndongo, S., Leye,Y., Diouma,A., Dieng, M.T., Ka, E.F., Ka, M.M. and Moreira-Diop, T. (2011) Présentation initiale du lupus érythémateux systémique au Sénégal. Médecine d’Afrique noire, 58, 156-160.
[7] Doualla Bija, M., Luma Namme, H., Ashuntantang, G., Epée, H., Kemta, F., Kwedi, F., Ngatat, C. and Ngandeu Singwe, M. (2014) Clinical Presentation, Treatment and Outcome of Patients with Systemic Lupus Erythematosus Seen at a Rheumatology Clinic in Douala, Cameroon. Health Sciences and Disease, 15, 1-5.
[8] Bouatba, L., Bachir, H., Ammouri, W., Maamar, M., Harmouche, H., Adnaoui, M. and Tazi Mezalek, Z. (2014) Lupus érythémateux systémique au Maroc: Etude analytique monocentrique de 440 patients. Revue de médecine interne, 35, A96-A200.
http://dx.doi.org/10.1016/j.revmed.2014.10.243
[9] Louzir, B., Othmani, S. and Ben Abdelhafidh, N. (2003) Le lupus érythémateux systémique en Tunisie. étude multi- centrique nationale. à propos de 295 observations. La revue de médecine interne, 24, 768-774.
http://dx.doi.org/10.1016/S0248-8663(03)00250-9
[10] Vilá, L.M., Mayor, A.M., Valentín, A.H., Garcia-Soberal, M. and Vilá, S. (1999) Clinical and Immunological Manifestations in 134 Puerto Rican Patients with Systemic Lupus Erythematosus. Lupus, 8, 279-286.
http://dx.doi.org/10.1191/096120399678847803
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