Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies

Read  full  paper  at:http://www.scirp.org/journal/PaperInformation.aspx?PaperID=55852#.VTcAjNKqpBc

ABSTRACT

Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, the other 20 patients had normal umbilical and uterine artery doppler waveforms. After the delivery, blood samples were taken from umbilical artery of double clemped umbilical cord for blood gas parameters, EPO and CD33 levels. Sociodemographic findings, antepartum, intrapartum test results, labor and delivery characteristics and newborn examination results were recorded. Blood gas parameters, EPO and CD33 levels between groups were analyzed. Mann-Whitney U test and t-test were used as statistical methods. Results: There were no differences between parity, gestational ages and newborn weights of the groups. Cord blood CD33 and EPO levels of group with abnormal umbilical and uterine artery doppler waveforms were significantly higher than group with normal umbilical and uterine artery doppler waveforms (p < 0.01). Conclusion: Pathology on doppler screen shows to us a connection between chronic hypoxemia and abnormal on doppler screen. Preference of high blood CD33 levels for cord blood transplantation especially during last years can also be used with preference of cord blood with abnormal doppler findings.

Cite this paper

Karaca, N. , Bolluk, G. , Akpak, Y. , Erken, A. and Oral, S. (2015) Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies. Open Journal of Obstetrics and Gynecology, 5, 234-238. doi: 10.4236/ojog.2015.54034.

References

[1] Rosner, M., Dar, P., Reimers, L.L., McAndrew, T. and Gebb, J. (2014) First-Trimester 3D Power Doppler of the Uteroplacental Circulation Space and Fetal Growth Restriction. American Journal of Obstetrics & Gynecology, 211, 521.e1-521.e8.
http://dx.doi.org/10.1016/j.ajog.2014.05.015
[2] Alfirevic, Z., Stampalija, T. and Gyte, G.M. (2013) Fetal and Umbilical Doppler Ultrasound in High-Risk Pregnancies. Cochrane Database Syst Rev, 11, Article ID: CD007529.
http://dx.doi.org/10.1002/14651858.CD007529.pub3
[3] Breborowicz, A., Dubiel, M., Pietryga, M., Breborowicz, G.H. and Gudmundsson S. (2014) Fetal Pulmonary and Cerebral Artery Doppler Velocumetry in Normal and High Risk Pregnancy. Ginekologia Polska, 85, 26-30.
[4] Whitehead, C.L., Teh, W.T., Walker, S.P., Leung, C., Larmour, L. and Tong, S. (2013) Circulating MicroRNAs in Maternal Blood as Potential Biomarkers for Fetal Hypoxia in-Utero. PLoS One, 8, e78487.
http://dx.doi.org/10.1371/journal.pone.0078487
[5] Kim, W.S., Zhu, Y., Deng, Q., Chin, C.J., He, C.B., Grieco, A.J., Dravid, G.G., Parekh, C., Hollis, R.P., Lane, T.F., Bouhassira, E.E., Kohn, D.B. and Crooks, G.M. (2014) Erythropoiesis from Human Embryonic Stem Cells through Erythropoietin-Independent AKT Signaling. Stem Cells, 32, 1503-1514.
http://dx.doi.org/10.1002/stem.1677
[6] Girsen, A., Makikallio, K., Hiilesmaa, V., Hamalainen, E., Teramo, K. and Rasanen, J. (2007) The Relationship between Human Fetal Cardiovascular Hemodynamics and Serum Erythropoietin Levels in Growth-Restricted Fetuses. American Journal of Obstetrics and Gynecology, 196, 467.e1-467.e6.
http://dx.doi.org/10.1016/j.ajog.2006.12.032
[7] Desplat, V., Faucher, J., Mahon, X., Sbarba, D., Praloran, V. and Ivanovic, Z. (2002) Hypoxia Modifies Proliferation and Differantiation of CD34+ CML Cells. Stem Cells, 20, 347-354.
http://dx.doi.org/10.1634/stemcells.20-4-347
[8] Ivanovic, Z., Hermitte, F., Grange, P., Dazey, B., Belloc, F., Lacombe, F. and Vezon, G. (2004) Simultaneous Maintenance of Human Cord Blood SCID-Repopulating Cells and Expansion of Committed Progenitors at Low O2 Concentration (3%). Stem Cells, 22, 716-724.
http://dx.doi.org/10.1634/stemcells.22-5-716
[9] Danet, G., Pan, Y., Luongo, J., Bonnet, D. and Simon, C. (2003) Expansion of Human SCID-Repopulating Cells under Hypoxic Conditions. The Journal of Clinical Investgation, 112, 126-135.
http://dx.doi.org/10.1172/JCI17669
[10] Kurmanavicius, J., Florido, I., Wisser, J., Hebisch, G., Zimmermann, R., Müler, R., Huch, R. and Huch, A. (1997) Reference Resistance Indices of the Umbilical, Fetal Middle Cerebral and Uterine Arteries at 24-42 Weeks Gestation. Ultrasound Obstet Gynecol, 10, 112-120.
http://dx.doi.org/10.1046/j.1469-0705.1997.10020112.x
[11] Ozeren, M., Dinc, H., Ekmen, ü., Senekayli, C. and Aydemir, V. (1999) Umbilical and Middle Cerebral Artery Doppler Indices in Patients with Preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 82, 11-16.
http://dx.doi.org/10.1016/S0301-2115(98)00167-5
[12] Acharya, G., Wilsgaard, T., Bernsten, G.K., Maltau, J.M. and Kiserud, T. (2005) Reference Ranges for Serial Measurements of Blood Velocity and PI at the Intra-Abdominal Portion and Fetal and Placental Ends of the Umbilical Artery. Ultrasound in Obstetrics & Gynecology, 26, 162-169.
http://dx.doi.org/10.1002/uog.1902
[13] Teramo, K.A. and Widness, J.A. (2009) Increased Fetal Plasma and Amniotic Fluid Erythropoietin Concentrations: Markers of ?ntrauterine Hypoxia. Neonatology, 95, 105-116.
http://dx.doi.org/10.1159/000153094
[14] Eckardt, K., Boutellier, U., Kurtz, A., Schopen, M., Koller, A. and Bauer, C. (1989) Rate of Erythropoietin Formation in Humans in Response to Acute Hypobaric Hypoxia. Journal of Applied Physiology, 66, 1785-1788.
[15] Ruth, V., Widness, J., Clemons, G. and Raivio, K. (1990) Postnatal Changes in Serum Immunoreactive EPO in Relation to Hypoxia before and after Birth. The Journal of Pediatrics, 116, 950-954.
http://dx.doi.org/10.1016/S0022-3476(05)80659-6
[16] Jazayeri, A., Politz, L., Tsibris, J., Queen, T. and Spellacy, W.N. (2000) Fetal EPO Levels in Pregnancies Complicated by Meconium Passage: Does Meconium Suggest Fetal Hypoxia? American Journal of Obstetrics & Gynecology, 183, 188-190.
http://dx.doi.org/10.1016/S0002-9378(00)20815-6
[17] Richey, S.D., Ramin, S.M., Bawdon, R.E., Roberts, S.W., Dax, J., Roberts, J. and Gilstrap, L.C. (1995) Markers of Acute and Chronic Asphyxia in Infants with Meconium-Stained Amniotic Fluid. American Journal of Obstetrics & Gynecology, 172, 1212-1215.
http://dx.doi.org/10.1016/0002-9378(95)91481-1
[18] Johnson, J.W., Richards, D. and Wagaman, R. (1990) The Case for Routine Umbilical Blood Acid-Base Studies at Delivery. American Journal of Obstetrics and Gynecology, 162, 621-625.
http://dx.doi.org/10.1016/0002-9378(90)90970-I
[19] Yeomans, E.R., Hauth, J.C., Gilstrap 3rd, L.C. and Strickland, D.M. (1985) Umbilical Cord pH, pCO2, and Bicarbonate Following Uncomplicated Term Vaginal Deliveries. American Journal of Obstetrics and Gynecology, 151, 798-800.
http://dx.doi.org/10.1016/0002-9378(85)90523-X
[20] Hamed, H.O. (2013) Intrapartum Fetal Asphyxia: Study of Umbilical Cord Blood Lactate in Relation to Fetal Heart Rate Patterns. Archives of Gynecology and Obstetrics, 287, 1067-1073.
http://dx.doi.org/10.1007/s00404-012-2694-7
[21] Desplat, V., Faucher, J., Mahon, X., Sbarba, D., Praloran, V. and Ivanovic, Z. (2002) Hypoxia Modifies Proliferation and Differantiation of CD34+ CML Cells. Stem Cells, 20, 347-354.
http://dx.doi.org/10.1634/stemcells.20-4-347
Advertisements

发表评论

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / 更改 )

Twitter picture

You are commenting using your Twitter account. Log Out / 更改 )

Facebook photo

You are commenting using your Facebook account. Log Out / 更改 )

Google+ photo

You are commenting using your Google+ account. Log Out / 更改 )

Connecting to %s