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Author(s)
1Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China.
2Department of Thoracic Surgery, Affiliated Hospital of Military Medical Science Academy of the PLA, Beijing, China.
3The Second Artillery General Hospital, Beijing, China.
2Department of Thoracic Surgery, Affiliated Hospital of Military Medical Science Academy of the PLA, Beijing, China.
3The Second Artillery General Hospital, Beijing, China.
Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3 in lung adenocarcinoma cells. Based on the importance role of STAT3 in cell proliferation and survival, we can construct an adenovirus vector of PIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, when STAT3 was activated by radiation, the expression of PIAS3 will be increased at the same time; this lead to the inhibition of invasion and metastasis caused by STAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.
KEYWORDS
Cite this paper
Gao, L. , Yu, Q. , Li, F. , Feng, J. , Lu, X. , Liu, Q. and Su, X. (2014) Inhibition of Radiation-Induced Lung Adenocarcinoma Cell Metastasis by Adenovirus of PIAS3 Overexpression Driven by Radiation-Inducible Promoter (Ad-pig3RRP-PIAS3). Journal of Cancer Therapy, 5, 1362-1365. doi: 10.4236/jct.2014.514136.
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